ESR 10 - Functional liposomes and polymersomes with selective targeting

The main objective of ESR10 shall be to develop cell-like vesicles from the self-assembly of biocompatible amphiphilic diblock copolymers or from the coassembly ofphospholipids with polymers having a phospholipid end-group. Poly(2-oxazoline)s andpoly(2-oxazine)s will be developed as hydrophilic part of these structures as these havebeen shown to more efficient in the suppression of non-specific interactions, at least onsolid substrates, which will be extended to polymersomes and liposomes here.Furthermore, different synthetic strategies to allow controlled post-modifications withsaccharides will be developed, involving end-group and side-chain modificationstrategies.